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rpmA [2017-07-26 18:33:35]
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rpmA [2017-07-26 18:33:35]

ribosomal protein
locus
BSU27940
pI
10.76
mw
10.23 kDa
protein length
94 aa Sequence Blast
gene length
282 bp Sequence Blast
function
translation
product
ribosomal protein L27 (BL24)
essential
yes
synonyms
Outlinks
KEGGBsubCycSubtiListUniProtExpression Browser

Genomic Context

      

categories

  • [category|SW 3|Information processing] → [category|SW 3.3|Protein synthesis, modification and degradation] → [category|SW 3.3.1|Translation] → [category|SW 3.3.1.4|Ribosomal proteins]
  • [category|SW 6|Groups of genes] → [category|SW 6.1|Essential genes]

    • Gene

    Coordinates
    2,854,880 → 2,855,164

    Phenotypes of a mutant

  • essential [Pubmed|23002217,12682299]

    • The protein

    Protein family

  • [SW|ribosomal protein] L27P family (according to Swiss-Prot)

    • Modification

  • the N-terminal extension is cleaved off by [protein|B27548A4BBF396C9BA102A80ACB08B21262CEA30|Prp] [Pubmed|25388641]

    • Structure

  • [PDB|3J9W] (the [SW|ribosome]) [Pubmed|25903689]

    • [SW|Localization]

  • cytoplasm (according to Swiss-Prot)

    • Additional information

  • the protein is significantly underrepresented in 45S assembly intermediates that accumulate upon depletion of [protein|54CD247926F7FABE4ACE85EB7021B62500B47260|RbgA] [Pubmed|24335279]

    • Expression and Regulation

    Operons

    genes
    [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
    description
    [Pubmed|22383849]

    regulatory mechanism

  • [regulon|stringent response|stringent response]: negative regulation, in [regulon|stringent response|stringent response]

    • regulation

  • [protein|CEE73284EFC0DBE8870CE0B474922DED79475A57|RelA] dependent downregulation (Class I) during stringent response [Pubmed|11948165]
  • likely autorepression of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] operon expression upon binding of excess of one ribosomal protein to the untranslated region of the [gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]→[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA] mRNA [Pubmed|17616982]
    • view in new tab

    genes
    [gene|AB2A3422277040107AAF90358BBE58608F8E0738|spoIVFA]-[gene|8801B095C2CE36F3E0B9DBBF489FFB217087DC0A|spoIVFB]-[gene|11927EB0448839D047EC7BF70EC65156DAB481D3|rplU]-[gene|B27548A4BBF396C9BA102A80ACB08B21262CEA30|prp]-[gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
    description
    [Pubmed|22383849]

    regulation

  • expressed early during sporulation in the mother cell ([protein|search|SigE], [SW|SpoIIID]) [Pubmed|15699190,1942049,15383836]

    • additional information

  • the domains that inhibits [protein|search|SpoIVFB] is cleaved off by [protein|search|CtpB] (second cleavage) [PubMed|24243021]
    • view in new tab

    genes
    [gene|4626C659D6F1A81CCC94030F1CBAF7FEC3DE19CA|rpmA]
    description
    [Pubmed|8969504]
    view in new tab

    References

  • 19653700,8969504,23002217,24335279,25388641,22383849,25903689